Synergistic Protection of Mice against Plague with Monoclonal Antibodies Specific for the F1 and V Antigens of Yersinia pestis
Open Access
- 1 April 2003
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (4) , 2234-2238
- https://doi.org/10.1128/iai.71.4.2234-2238.2003
Abstract
Monoclonal antibodies specific for Yersinia pestis V antigen and F1 antigen, administered singly or in combination, protected mice in models of bubonic and pneumonic plague. Antibodies showed synergy when administered prophylactically and as a therapy 48 h postinfection. Monoclonal antibodies therefore have potential as a treatment for plague.Keywords
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