INCOMPATIBILITY OF RUTIN AND SULFONAMIDES

Publisher Website
Google Scholar
Abstract
To the Editor:— The increasing use of rutin will undoubtedly be stimulated even more by your editorial on rutin therapy, page 247 of the January 25 issue of The Journal. A recent development in the case which I reported and which you quoted in the editorial leads me to call attention to my experience. This development represents a potential pitfall which was most distressing to my patient; in reporting it I hope that others may avoid a similar difficulty. My patient continued entirely well until the recent development of a urinary tract infection which led to the administration of sulfadiazine by his urologist. During the administration of the sulfadiazine the patient began to have nosebleeds again and evidence of major gastrointestinal hemorrhage. The latter finally required readmission to the hospital and three transfusions. In the meantime I got in touch with Dr. Griffith in Philadelphia and he advised me that

This publication has 0 references indexed in Scilit: