STOMATITIS DUE TO STREPTOMYCIN
- 16 October 1948
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 138 (7) , 495-496
- https://doi.org/10.1001/jama.1948.62900070001006
Abstract
Since the use of streptomycin has become widespread in the treatment of many infections in human beings, the question of its untoward side reactions assumes importance. To date, many reports of toxic reactions following its use have appeared in the literature.1 One of the most constant of these reactions is temporary or permanent impairment of the eighth nerve apparatus.2 No other neurologic involvement following streptomycin therapy has been reported. Local irritations at the site of injection,3 fever,4 dermatitis,5 pruritis, rhinitis, conjunctivitis,1b swelling of the buccal mucous membranes, flushes,4 and eosinophilia have all been noted, either singly or in combination, and are considered manifestations of hypersensitivity to the drug. This report deals with 3 cases of painful stomatitis, at first resembling the aphthous variety, which developed during the treatment of pulmonary and extrapulmonary tuberculosis with streptomycin. REPORT OF CASES Case 1.— L.B., a 55Keywords
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