IMMUNE-RESPONSE TO IMMUNIZATION VIA ANTERIOR-CHAMBER OF EYE .1. F1 LYMPHOCYTE-INDUCED IMMUNE DEVIATION

1 January 1977

journal article
research article

Vol. 118 (3) , 809-814

Abstract

The immunizing abilities of alloantigens placed within the anterior chamber of the eye were studied in inbred rats. Although intracameral inoculation of F1 hybrid lymphocytes into parental strain recipients elicited cell- and antibody-mediated immunity, a delimited interval was identified postinoculation during which the systemic cell-mediated immune response was suppressed as indicated by prolonged acceptance of orthotopic skin allografts. The prompt appearance of hemagglutinating antibodies in the serum of immunized rats followed a time course which coincided with the suppression of cell-mediated immunity and suggested that the 2 events are causally related. Since exposure to allogeneic antigens on lymphoid cells via the anterior chamber elicits a transient suppression in cell-mediated immunity, whereas humoral immunity is preserved, the phenomenon resembles immune deviation.

This publication has 6 references indexed in Scilit:

Immunization with Skin Isografts Taken from Tolerant Mice
Science, 1967
TOLERANCE TO BOVINE GAMMA-GLOBULIN IN ADULT GUINEA PIGS
1966
SELECTIVE AND SPECIFIC INHIBITION OF 24 HOUR SKIN REACTIONS IN GUINEA-PIG .1. IMMUNE DEVIATION - DESCRIPTION OF PHENOMENON AND EFFECT OF SPLENECTOMY
1965
Studies on homografts of foetal and infant skin and further observations on the anomalous properties of pouch skin grafts in hamsters
Proceedings of the Royal Society of London. B. Biological Sciences, 1964
The transplantation of normal tissues: with special reference to auto- and homotransplants of thyroid and spleen in the anterior chamber of the eye, and subcutaneously, in guinea-pigs
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1950
IMMUNITY TO HOMOLOGOUS GRAFTED SKIN .3. THE FATE OF SKIN HOMOGRAFTS TRANSPLANTED TO THE BRAIN, TO SUBCUTANEOUS TISSUE, AND TO THE ANTERIOR CHAMBER OF THE EYE
1948