Metabolism of bladder carcinogens. 2. The metabolic path of 2-[8-14C]naphthylamine in the rabbit and in the rat

Publisher Website
Google Scholar
Abstract
Rabbits injected intraperitoneally with 2-(8-C14) naphthylamine (approximately 1 mg) retain radioactivity in the blood for several weeks. This activity is shared between the plasma and cells. In rats, activity is detectable in the blood for about the same length of time, but after 11 days it is entirely in the cells. In one day after intraperitoneal injection of approximately 1 mg of 2-(8-C14) naphthylamine in rabbits about 90% of the dose is excreted in the urine and feces. The initial excretion in the urine is very rapid (over 50% of the dose in 2 hours, compared with 22% for rats). Total urinary excretion in the rabbit is about 80%. Excretion of radioactive material into the gut of rabbits, both by the biliary route and otherwise, is demonstrated. The total amount reaching the gut is much less than in rats, mainly because excretion in the bile is much lower. Reabsorption of active material from the gut is shown to occur. The concentration of radioactivity in the bile and the blood of rabbits varies in a closely similar manner. The actual concentration in the bile at a given time is considerably higher than in the blood and may exceed it from 3 to over 30 times in anesthetized rabbits with cannulated common bile ducts.

This publication has 4 references indexed in Scilit: