Activation-energy landscape for metastable RNA folding
- 1 September 1990
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review A
- Vol. 42 (6) , 3657-3659
- https://doi.org/10.1103/physreva.42.3657
Abstract
We consider the relaxation kinetics for folding intermediate structures in random uncorrelated RNA chains. Folding patterns correspond to intrachain secondary structures. We make use of a Monte Carlo simulation that mimics a Markov process to study the refolding dynamics. This is done to obtain the time-dependent behavior of the activation energies. We conclude that the mechanism of relaxation to the equilibrium secondary structure is compatible with the random-energy model as the thermodynamic limit is approached.Keywords
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