Structure‐based systems biology: a zoom lens for the cell
- 16 February 2005
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 579 (8) , 1854-1858
- https://doi.org/10.1016/j.febslet.2005.02.014
Abstract
Systems biology seeks to explain complex biological systems, such as the cell, through the integration of many different types of information. Here, we discuss how the incorporation of high-resolution structural data can provide key molecular details often necessary to understand the complex connection between individual molecules and cell behavior. We suggest a process of zooming on the cell, from global networks through pathways to the precise atomic contacts at the interfaces of interacting proteins.Keywords
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