The effects of fluoroacetate, malonate and acid-base balance on the renal disposal of citrate

Publisher Website
Google Scholar
Abstract
Fluoroacetate does not increase urinary citrate despite citrate accumulation in renal tissue. Hydrogen carbonate increases citrate excretion and renal-tissue citrate. This urinary increaseis not influenced by fluoroacetate, despite doubly increased kidney citrate. Fluoroacetate does not interfere with the excretion of a-oxoglutarate after either hydrogen carbonate or malate. Sodium hydrogen malonate, sodium hydrogen malate and sodium hydrogen succinate increase citrate excretion in a manner quantitatively similar to the increase seen with equimolar sodium hydrogen carbonate. The free acids succinic acid and L-malic acid did not increase citrate excretion and it is suggested that the acid-base balance is an overriding factor. The fact that malonate increased citrate excretion whereas fluoroacetate did not is discussed in terms of acid-base changes.