Mimicry of Biological Macromolecules by Polyaromatic Anionic Compounds
- 1 October 1993
- journal article
- research article
- Published by SAGE Publications in Journal of Bioactive and Compatible Polymers
- Vol. 8 (4) , 317-337
- https://doi.org/10.1177/088391159300800402
Abstract
The preparation, characterization and biological properties of some polyanionic polymers are reported. These polymers are constructed with repeating phenol-based monomers. The anionic groups attached to the aro matic nucleus provide the basis for binding to basic domains of proteins. Scaf fold flexibility permits the polyanionic polymers to adopt low energy conforma tions suitable for interacting with coagulation proteins and an anti-DNA monoclonal antibody. Structure activity relationships (SAR) and comparisons with aurintricarboxylic acid are described. The polymers doubled the clotting time in the APTT assay with value ranging from 10-1000 μg/mL. Binding to an anti-DNA monoclonal antibody occurred with ICso values of 0.3-5.0 μg/mL.Keywords
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