Comparison of plasma and intraluminal amino acid profiles in man after meals containing a protein hydrolysate and equivalent amino acid mixture.
Open Access
- 31 July 1982
- Vol. 23 (8) , 670-674
- https://doi.org/10.1136/gut.23.8.670
Abstract
Plasma and intraluminal amino acid profiles were compared in normal subjects 30, 60, 120, 180 minutes after meals containing either a peptide-rich protein hydrolysate (H) or an equivalent free amino acid mixture (AA) as the nitrogen source. Except for asparagine (30 minutes) and glutamine (30 and 60 minutes), which were absorbed to a significantly (p less than 0.05) greater extent from the peptide mixture, there were no significant differences in the plasma increments of the remaining 13 amino acids at any time interval after the meals. Positive correlations (p less than 0.01 or less) between the amino acid composition of the hydrolysate and amino acid meals and both (1) the post-prandial increments in the individual plasma amino acids and (2) the residual intraluminal amino acid content suggested that the amino acid composition of ingested protein, rather than specialised free amino acid and peptide transport systems, dictated the pattern of amino acid absorption. The studies provide no evidence that peptides rather than free amino acids are the ideal nitrogen source in elemental diets.This publication has 21 references indexed in Scilit:
- Effects of concentration on in vivo absorption of a peptide containing protein hydrolysate.Gut, 1982
- Comparison of the absorption of two protein hydrolysates and their effects on water and electrolyte movements in the human jejunum.Gut, 1980
- Comparison of oral feeding of peptide and amino acid meals to normal human subjectsGut, 1979
- Intestinal absorption of peptidesPhysiological Reviews, 1975
- Changes in plasma amino acid concentrations in man after ingestion of an amino acid mixture simulating casein, and a tryptic hydrolysate of caseinBritish Journal of Nutrition, 1975
- Jejunal absorption of an amino acid mixture simulating casein and an enzymic hydrolysate of casein prepared for oral administration to normal adultsBritish Journal of Nutrition, 1975
- Absorption of Amino Acids from an Amino Acid Mixture Simulating Casein and a Tryptic Hydrolysate of Casein in ManClinical Science, 1973
- Protein Digestion in Human Intestine as Reflected in Luminal, Mucosal, and Plasma Amino Acid Concentrations after MealsJournal of Clinical Investigation, 1973
- Amino Acids and Glucose in Human Blood Plasma after Beef and Nonprotein MealsExperimental Biology and Medicine, 1969
- The Levels of Individual Free Amino Acids in the Plasma of Normal Man at Various Intervals After a High-Protein Meal1Journal of Clinical Investigation, 1958