Habituation in the single cell: diminished secretion of norepinephrine with repetitive depolarization of PC12 cells.
- 1 March 1990
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 87 (5) , 2031-2035
- https://doi.org/10.1073/pnas.87.5.2031
Abstract
Neuronally differentiated PC12 cells secrete decreasing amounts of [3H]norepinephrine when repetitively stimulated by depolarizing concentrations of potassium ion. The decreasing response shows attributes that have been classically ascribed to response habituation, a behavior commonly observed in nervous systems but found here in a homogeneous cell type. Alteration of the habituation pattern was caused by activators of the protein kinase C pathway and of voltage-gated calcium channels.This publication has 41 references indexed in Scilit:
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