FACILE THIOLYTIC REMOVAL OF THE o‐NITROPHENYLSULPHENYL AMINO‐PROTECTING GROUP
- 1 March 1979
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 13 (3) , 315-319
- https://doi.org/10.1111/j.1399-3011.1979.tb01885.x
Abstract
2-Mercaptopyridine was used to effect the selective, mild and efficient cleavage of the o-nitrophenylsulphenyl amino-protecting group from several amino acids and peptides. By utilization of this reagent a stepwise synthesis of the tetrapeptide Thr-Lys-Leu-Arg([Leu3]tuftsin) was successfully achieved. The potential use of 2-mercaptopyridine in mechanized peptide synthesis via the polymeric reagents approach is discussed.Keywords
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