Gastric Emptying and Acid Secretion during the First Postoperative Year after Parietal Cell Vagotomy

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Abstract
Gastric emptying was obtained in 19 patients operated upon with parietal eel] vagotomy (PCV) without pyloroplasty. As test meals were used saline and 10% glucose solution respectively. The emptying tests were performed preoperatively, one month, six months, and one year after surgery. Gastric content and meal remaining 10 minutes after the instillation of saline and 30 minutes after the instillation of glucose solution were estimated. Both gastric content and meal remaining of the saline meal were significantly less one and six months postoperatively but one year after PCV there was no significant difference compared with preoperatively, a fact which gave the impression of a normalization of the gastric emptying of the saline. Gastric content and meal remaining of the glucose solution were significantly less at every test occasion after PCV compared with preoperatively. When volume emptied, i.e. gastric secretion and meal, was calculated, this volume was significantly larger at all saline tests as well as glucose tests postoperatively than before PCV. The basal acid and the peak acid output after insulin and pentagastrin stimulation were studied preoperatively, one month and one year after the surgery. There was a significant decrease of all parameters studied one month and one year after the surgery as compared with the preoperative values. However, all parameters increased significantly from one month to one year after surgery. There was no change in gastric emptying rate of either saline or glucose solution parallel with the increase of gastric acid secretion during the first postoperative year after PCV.