Don't use minocycline as first line oral antibiotic in acne

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Abstract
The clinical problem Most people develop acne vulgaris at some point in life. Typified by inflammation of hair follicles and accompanying sebaceous glands, acne may require oral antibacterial treatment, particularly in those with moderate to severe disease (an estimated 11% of adolescents1). Minocycline is a common choice of drug and is often wrongly assumed to be more effective, easier to take, and less likely to cause bacterial resistance than other tetracyclines. Search methods We searched Medline and the Cochrane Library to identify published randomised controlled trials and systematic reviews that assessed the safety and efficacy of oral minocycline in the treatment of acne vulgaris. We also consulted widely among specialists and generalists, as well as drug companies, to identify relevant published evidence.