A model system for the analysis of gene exclusion: cystic fibrosis and chromosome 19.
Open Access
- 1 October 1986
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 23 (5) , 417-420
- https://doi.org/10.1136/jmg.23.5.417
Abstract
We have used multilocus analysis to exclude the cystic fibrosis locus from six polymorphic DNA markers covering most of chromosome 19. A substantial increase in the confidence for exclusion was obtained using the computer programme LINKAGE compared to analysis of pairwise lod scores. A structured approach to the analysis of linkage to autosomal recessive inherited diseases where the biochemical defect is not known is described.This publication has 27 references indexed in Scilit:
- Somatic cell genetic studies of the cystic fibrosis mucociliary inhibitorClinical Genetics, 2008
- LINKAGE OF COL1A2 COLLAGEN GENE TO CYSTIC FIBROSIS, AND ITS CLINICAL IMPLICATIONSThe Lancet, 1985
- Cystic Fibrosis Locus Defined by a Genetically Linked Polymorphic DNA MarkerScience, 1985
- Localization of cystic fibrosis locus to human chromosome 7cen–q22Nature, 1985
- A closely linked genetic marker for cystic fibrosisNature, 1985
- Linkage relationships of paraoxonase (PON) with other markers: indication of PON‐cystic fibrosis syntenyClinical Genetics, 1985
- The structural gene for human coagulation factor X is located on chromosome 13q34Cytogenetic and Genome Research, 1985
- Higher Bioelectric Potentials Due to Decreased Chloride Absorption in the Sweat Glands of Patients with Cystic FibrosisNew England Journal of Medicine, 1983
- Increased Bioelectric Potential Difference across Respiratory Epithelia in Cystic FibrosisNew England Journal of Medicine, 1981
- POSSIBLE LOCALISATION OF THE GENE FOR CYSTIC FIBROSIS OF THE PANCREAS TO THE SHORT ARM OF CHROMOSOME 5The Lancet, 1968