Precursors of human colon carcinoma: A serial section study of colectomy specimens
- 15 April 1981
- Vol. 47 (8) , 2007-2015
- https://doi.org/10.1002/1097-0142(19810415)47:8<2007::aid-cncr2820470818>3.0.co;2-w
Abstract
All polyps and strips of colonic mucosa 1 to 15 cm from tumor margins were examined for possible precursors of carcinoma in 24 patients undergoing partial colectomy for primary colorectal adenocarcinoma. Of 114 polyps found, 40.4% were adenomatous, and the remainder were hyperplastic or inflammatory or showed normal mucosa. No primarily dysplastic lesions, which could be interpreted as early de novocarcinomas, were found. Serial sections of mucosal strips revealed minute adenomatous foci in 3 of 24 patients, one of whom also showed several patches of exclusively dysplastic epithelium. This finding suggests that carcinomas may rarely arise de novo, but most carcinomas appear to be accompanied by (? preceded by) adenomatous changes.This publication has 16 references indexed in Scilit:
- On controlling colorectal cancerHuman Pathology, 1979
- The prevention of invasive cancer of the rectumCancer, 1978
- Benign (nonpolypoid) mucosal changes adjacent to carcinomas of the colonHuman Pathology, 1977
- The evolution of cancer of the colon and rectumCancer, 1975
- An investigation into the enzyme histochemistry of adenocarcinomas of human large intestine and of the transitional epithelium immediately adjacent to themGut, 1974
- Carcinoma in situ of the colonDiseases of the Colon & Rectum, 1970
- Structure and significance of metaplastic nodules in the rectal mucosaJournal of Clinical Pathology, 1968
- Observations on the origin of adenomatous epithelium of the colon.Serial section studies of minute polyps in familial polyposisCancer, 1963
- Small Primary Adenocarcinomas of the Colon and RectumPublished by American Medical Association (AMA) ,1962
- Relationship of Polyps of the Colon to Colonic CancerAnnals of Surgery, 1958