Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model
Open Access
- 31 January 2008
- journal article
- Published by Springer Nature in BMC Musculoskeletal Disorders
- Vol. 9 (1) , 15
- https://doi.org/10.1186/1471-2474-9-15
Abstract
External medication that is absorbed percutaneously may be used to reduce inflammation and relieve pain from acute injuries such as ankle sprains and bruises. The plaster method of percutaneous absorption for non-steroidal anti-inflammatory drugs (NSAIDs) was established in Japan in 1988. However, due to the possibility of a placebo effect, the efficacy of this method remains unclear. This experimental study was conducted to control for the placebo effect and to study the efficacy of the plaster method in relieving pain by using a rat model of inflammation.Keywords
This publication has 19 references indexed in Scilit:
- Effects of flurbiprofen and its enantiomers on the spinal c-Fos protein expression induced by noxious heat stimuli in the anaesthetized ratEuropean Journal of Pharmacology, 2000
- Changes in formalin-evoked spinal Fos expression and nociceptive behaviour after oral administration of Bufferin A (aspirin) and L-5409709 (ibuprofen+caffeine+paracetamol)Pain, 1997
- Ketoprofen produces profound inhibition of spinal c-Fos protein expression resulting from an inflammatory stimulus but not from noxious heatPain, 1996
- Concurrent reduction of inflammation and spinal Fos-LI neurons by systemic diclofenac in the ratNeuroscience Letters, 1995
- Carrageenin-evoked c-Fos expression in rat lumbar spinal cord: the effects of indomethacinEuropean Journal of Pharmacology, 1995
- Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious micePain, 1994
- Differential activation of c-fos in spinal neurones by distinct classes of noxious stimuliNeuroReport, 1993
- Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and junAnnual Review of Neuroscience, 1991
- Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cordJournal of Neuroscience, 1990
- Induction of c-fos-like protein in spinal cord neurons following sensory stimulationNature, 1987