EFFECTS OF SHORT-TERM ADMINISTRATION OF LARGE DOSES OF HUMAN GROWTH HORMONE ON CARBOHYDRATE METABOLISM IN ADULT, NON-DIABETIC, HYPOPHYSECTOMIZED WOMEN; STUDIES WITH 14C-LABELLED GLUCOSE

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Abstract
Five adult, non-diabetic, hypophysectomized women were given human growth hormone (HGH) in doses of 10-20 mg/d for 2-3 days (total dose 30-60 mg). HGH induced nitrogen retention as well as fasting - and excessive postprandial - hyperglycaemia and glycosuria. These changes disappeared when HGH-treatment was stopped. The findings were interpreted as demonstrating that the development of "idiohypophyseal" diabetes mellitus in human subjects is possible. Studies with C14-labelled glucose in these subjects showed that the turnover rate of glucose was decreased by HGH, and that the absolute values for peripheral disposal of glucose were unchanged in 3 patients, decreased in 1 and transitorily decreased in the 5th. Since the blood glucose level increased during HGH, the results of the C14-glucose studies were taken as evidence that peripheral glucose metabolism is depressed by HGH in man.

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