The glycogenolytic activity of some substituted salicylic acids

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Abstract
The effects of 10 substituted salicylic acids on liver glycogen concentration in the mouse have been studied. Doses (10 mg) of m-hydroxybenzoic acid, p-hydroxybenzoic acid, gentisic acid, gamma-resorcylic acid and salicylamide had no effect on glycogen concentration. Salicylic acid, o-, m- and p-cresotic acid and 3-phenylsalicylic acid all possess glycogenolytic activity. A linear relationship was found between the difference in liver glycogen concentration between corresponding control and treated mice and log dose for salicylic acid. The relative molar potency ratios of o-cresotic acid and 3-phenylsalicylic acid as glycogenolytic compounds compared with salicylic acid for the males were o-cresotic acid 1.50, 3-phenylsalicylic acid, 2.68; for the females the respective values were 1.81 and 4.79. The relationship between glycogenolytic and metabolic-stimulant activity is discussed.