Diphenylhydantoin: Pre- and Postnatal Administration Alters Diazepam Binding in Developing Rat Cerebral Cortex
- 4 April 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 208 (4439) , 64-66
- https://doi.org/10.1126/science.7361107
Abstract
Close correlations between the development of the anticonvulsant effects of diphenylhydantoin and increases in tritiated diazepam binding were observed in rats from fetal day 16 to maturation. In contrast, significant decreases in tritiated diazepam binding were observed in 2- and 3-week-old rats that were exposed in utero to diphenylhydantoin. These changes can be correlated with reported increases in seizure susceptibility after prenatal exposure to diphenylhydantoin.Keywords
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