METHOTREXATE WITH CITROVORUM FACTOR RESCUE FOR NON-METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASMS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 48  (3) , 321-323
Abstract
Fifteen patients with nonmetastatic gestational trophoblastic neoplasms were treated with methotrexate and citrovorum factor. Complete and sustained remission was achieved in 14 of the 15 patients. Response to treatment was determined on the basis of serial serum human chorionic gonadotropin levels as measured by the .beta.-subunit radioimmunoassay. All patients developed nonmetastatic gestational trophoblastic neoplasms following evacuation of a molar pregnancy. The known histologic diagnosis in all cases was hydatidiform mole. No significant toxicity was encountered despite careful monitoring of marrow, hepatic, renal, neurologic and mucocutaneous parameters. Up to Jan. 31, 1976, duration of remission ranged from 2-14 mo.