EXPRESSION AND FUNCTION OF I REGION PRODUCTS ON IMMUNOCOMPETENT CELLS .1. I REGION PRODUCTS IN T-B INTERACTION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 119  (2) , 744-748
Abstract
The anti-Lac [p-azophenyl .beta.-D lactoside] B [bone marrow-derived] precursor cells from BALB/c (H-2)d mice which survive cytotoxic treatment with anti-Iak and complement will respond to Lac-KLH [keyhole limpet hemocyanin] in culture, but require more KLH helper T [thymus-derived] cells than unselected B cell populations or B cells surviving anti-Ig[immunoglobulin] killing. These findings are not explainable by the classical Poisson assumption of a constant target of T cell-B cell interaction. A T cell-B cell interaction theory is proposed with a variable Ia [immune response-associated] antigen target on the B cell surface. The theory quantitatively predicts the observed dose response relationships and implies that Ia molecules on B cells are cell interaction structures.