An information theory quality score for reagent sera

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Abstract
A quality score adapted from information theory is of interest in evaluating HLA typing sera in that it permits the evaluation of a panel of sera detecting a given specificity from the quality characteristics of the sera considered individually. The empirical question of additivity of quality scores is considered using data of the 8th International Histocompatibility Workshop. Additivity is only approximate, which indicates that panels of sera will not be quite as good as would be predicted by summing quality scores of the component sera. Methodological problems regarding estimation of the quality score are considered. The information quality score is related to other indices of serum quality for the special case in which reactions are scored as positive or negative.

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