Saturation of mismatch repair in the mutD5 mutator strain of Escherichia coli
- 1 August 1989
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 171 (8) , 4494-4497
- https://doi.org/10.1128/jb.171.8.4494-4497.1989
Abstract
The mutD (dnaQ) gene of Escherichia coli codes for the proofreading activity of DNA polymerase III. The very strong mutator phenotype of mutD5 strains seems to indicate that their postreplicational mismatch repair activity is also impaired. We show that the mismatch repair system of mutD5 strains is functional but saturated, presumably by the excess of DNA replication errors, since it is recovered by inhibiting chromosomal DNA replication. This recovery depends on de novo protein synthesis.This publication has 40 references indexed in Scilit:
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