Single-voided urine metanephrine assays in screening for pheochromocytoma

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Abstract
To facilitate screening for pheochromocytoma, the use of single voided, spot urine specimens was validated for the determination of total metanephrines. Metanephrine excretion was quite constant throughout the day and night in 10 patients with essential hypertension and 7 patients with pheochromocytoma. The levels in single voided specimens were closely correlated to those in 24 h specimens in 100 hypertensive subjects. The mean .+-. 2 SD metanephrine excretion in single voided urine specimens from 500 hypertensive subjects was 0.351 .+-. 0.356 .mu.g/mg of creatinine.

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