Diversity of disease in childhood pulmonary tuberculosis
- 1 June 2005
- journal article
- review article
- Published by Taylor & Francis in Paediatrics and International Child Health
- Vol. 25 (2) , 79-86
- https://doi.org/10.1179/146532805x45665
Abstract
Many factors can influence the dynamic balance that exists between the host and the pathogen (M. tuberculosis), but the host immune response seems to be the most important. This is illustrated by the vulnerability of immune-compromised individuals to develop tuberculosis and by the age-related spectrum of disease witnessed in immune-competent children. This age-related spectrum of disease reflects the ontogeny of the host immune response towards M. tuberculosis. Renewing our focus on the ontogeny of the immune response in children might provide valuable insights to direct future research regarding tuberculosis prevention, vaccine development and treatment.Keywords
This publication has 22 references indexed in Scilit:
- A proposed radiological classification of childhood intra-thoracic tuberculosisPediatric Radiology, 2004
- Use of Genetic Distance as a Measure of Ongoing Transmission of Mycobacterium tuberculosisJournal of Clinical Microbiology, 2003
- Different Strains ofMycobacterium tuberculosisCause Various Spectrums of Disease in the Rabbit Model of TuberculosisInfection and Immunity, 2003
- A marked difference in pathogenesis and immune response induced by differentMycobacterium tuberculosisgenotypesClinical and Experimental Immunology, 2003
- Molecular mechanisms regulating persistent Mycobacterium tuberculosis infectionMicrobes and Infection, 2003
- Human immunity to M. tuberculosis: T cell subsets and antigen processingTuberculosis, 2003
- Exogenous Reinfection as a Cause of Recurrent Tuberculosis after Curative TreatmentNew England Journal of Medicine, 1999
- The epidemiology of tuberculosis in gold miners with silicosis.American Journal of Respiratory and Critical Care Medicine, 1994
- Pathogenesis of tuberculosis: pathway to apical localizationTubercle and Lung Disease, 1994
- Airborne infectionThe American Journal of Medicine, 1974