Alkaline phosphatase in bile and urine. Excretion in patients with hepatobiliary disease

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Abstract
Patients with liver disease and elevated serum alkaline phosphatase were studied and in some cases had increased excretion of urine alkaline phosphatase after an inhibitor was removed from the urine by dialysis. Bile was collected from postoperative patients with T tubes and alkaline phosphatase determinations were made. The bile alkaline phosphatase was found to be increased in a number of patients with elevated serum alkaline phosphatase. These studies support the concept that the increased serum alkaline phosphatase in patients with liver disease is hepatic in origin and not due to impaired excretion by the liver.