Serotonin receptor affinity of cathinone and related analogs

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Abstract
A series of cathinone (.alpha.-aminopropiophenone) [a psychoactive principle of the shrub Catha edulis] analogs was examined using the isolated rat fundus preparation. (S)-(.sbd.)-Cathinone possesses twice the serotonin receptor affinity of (.+-.)-cathinone and 4 times the affinity of racemic amphetamine. Several derivatives of cathinone either possessed a lower affinity than the parent compound or did not interact with the receptors in a competitive manner. Several novel analogs, 1-(aminomethyl)-3,4-dihydronaphthalene hydrochloride, 4-(aminomethyl)-3-chromene hydrochloride and its 6-methoxy derivative, interact with serotonin receptors but in a fashion which is most likely dissimilar to the interaction of the substituted cathinone analogs.