T-bet or Not T-bet
- 7 November 2003
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 302 (5647) , 993-994
- https://doi.org/10.1126/science.1092040
Abstract
We depend on the efficiency of our adaptive immune system to combat pathogen invaders. Part of this protective response includes development of CD4 and CD8 effector T cells. As Hatton and Weaver discuss in their Perspective, key transcription factors regulating CD4 effector T cell development have been identified, whereas those governing the development of CD8 effectors have not. Hatton and Weaver describe new work showing that cooperation between two T-box transcription factors, T-bet and Eomesodermin, instigates the CD8 effector program ( Pearce et al.).Keywords
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