GABA uptake regulates cortical excitability via cell type–specific tonic inhibition
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- 7 April 2003
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 6 (5) , 484-490
- https://doi.org/10.1038/nn1043
Abstract
GABAA receptors can mediate both 'phasic' synaptic inhibition and a persistent 'tonic' form of signaling. We show that, in the presence of intact GABA uptake, guinea pig hippocampal interneurons, but not pyramidal cells, express a tonic GABAA receptor–mediated conductance. This conductance was pharmacologically distinct from spontaneous inhibitory postsynaptic currents (IPSCs). Inhibiting GABA uptake resulted in the expression of a comparable GABAA receptor–mediated tonic conductance in pyramidal cells. Reducing the tonic conductance in interneurons enhanced their excitability and the inhibitory drive to pyramidal cells. These results point to a role for cell type–dependent tonic inhibition in regulating cortical excitability.Keywords
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