The Effects Of Sucralfate Ingestion On Serum And Specific Tissue Aluminum Concentration In Normal Rats

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Abstract
The effects of sucralfate ingestion on serum and specific tissue aluminum (Al) accumulation were studied in normal rats fed either a control diet or the same diet supplemented with sucralfate. Although serum Al concentrations were not significantly different between the groups, animals fed sucralfate for 8 weeks had significantly higher bone but not brain or liver Al concentrations when compared with controls. This study indicates that 8 weeks exposure to Al in sucralfate leads to an increase in bone Al concentrations, without changes in serum Al concentrations, suggesting that serum Al concentration may be a poor predictor of gastrointestinal absorption and specific tissue retention of Al.