The chemotherapy of experimental leishmaniasis II. A dose response curve for the activity of sodium stibogluconate

1 October 1945

journal article
research article
Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene

Vol. 39 (2) , 133-145
https://doi.org/10.1016/0035-9203(45)90004-6

Abstract

Using hamsters as exptl. animals, a dose-response curve for the leishmanicidal activity of single doses of Na stibogluconate has been obtained. A period of 1 wk. is necessary for establishing such a curve for Sb compounds. A linear relationship exists between the log. of the dose and the log. of the ratio of parasite counts in splenic smears taken before and after treatment.

Keywords

This publication has 3 references indexed in Scilit:

The chemotherapy of experimental leishmaniasis. I. The spleen as an index of infection in the Syrian hamster
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1944
Notes on the Action of 4:4′-Diamidino Stilbene onLeishmania DonovaniandLeishmania Infantumin the Syrian HamsterCricetus Auratus
Pathogens and Global Health, 1941
The Evaluation of Drugs in Experimental Leishmaniasis
The American Journal of Tropical Medicine, 1941