Synthesis of the N-((1E)-Alkenyl)-(2Z,4Z)-heptadienamide Side Chain of Salicylihalamide A and Apicularens A and B
- 13 January 2000
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (3) , 407-408
- https://doi.org/10.1021/ol991388+
Abstract
The unstable N-((1E)-alkenyl)-(2Z,4Z)-heptadienamide side chain of salicylihalamide A (1) and apicularens A and B (3 and 4) has been prepared in one pot by the addition of (1Z,3Z)-hexadienylcuprate, prepared in situ from EtLi, CuBr·SMe2, and acetylene, to a (1E)-alkenyl isocyanate.Keywords
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