Fluorescence studies on P1,P3-dinucleoside triphosphates related to mRNA cap: Acidity and intramolecular stacking

1 January 1990

journal article
Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications

Vol. 55 (11) , 2765-2768
https://doi.org/10.1135/cccc19902765

Abstract

The fluorescence intensity of several P¹,P³-dinucleoside triphosphates related to mRNA cap-structure has been measured as a function of pH and temperature. The extent of intramolecular stacking has been estimated by comparing the intensities obtained with dinucleoside triphosphates to those of the corresponding monomers. The pK_a values of 7-alkylguanine moieties in both dimeric and monomeric compounds have been determined by fluorescence and absorption spectroscopy.

Keywords

FLUORESCENCE
CAP
DINUCLEOSIDE TRIPHOSPHATES
P3 DINUCLEOSIDE
FUNCTION
STRUCTURE

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