Studies on the Effect of Cyclophosphamide on T and B Lymphocytes in the Blood, Lymph Nodes, and Thymus of Normal Guinea Pigs

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Abstract
Cyclophosphamide administered three times at 48-hour intervals to normal guinea pigs caused a fall in the percentage of B lymphocytes and a rise in that of T lymphocytes in the blood. A single injection of cyclophosphamide caused little change in the percentage of T and B lymphocytes. There was a marked reduction in total lymphocyte count with both dose regimes with resultant falls in T and B cell levels when these were expressed as reacting cells/mm3 of blood. Cyclophosphamide, when injected three times at 48-hour intervals, caused the percentage of B lymphocytes to fall and that of T lymphocytes to rise in lymph nodes. There was no alteration in T or B lymphocyte levels in thymus following cyclophosphamide treatment.