Progesterone therapy in obese patients with sleep apnea
- 1 January 1979
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 139 (1) , 109-111
- https://doi.org/10.1001/archinte.139.1.109
Abstract
Seven morbidly obese patients with sleep-related upper airway obstruction (UAO) were studied before and during progesterone treatment. All subjects had severe daytime somnolence, and five of the seven had congestive heart failure. All subjects were studied for one or two consecutive baseline nights in the sleep laboratory. Six of the seven subjects showed a mean of greater than 100 UAOs. Patients were treated for two to four weeks with medroxyprogesterone acetate, 20 mg three times daily. At the end of the treatment period, the sleep studies were repeated. There was no significant difference in the incidence, mean duration, or rate per minute of apneic episodes occurring before and with progesterone treatment. Severe hypoxemia during sleep persisted with treatment, as did the occurrence of cardiac arrhythmias. There was a significant improvement in the waking Pao2with progesterone treatment. (Arch Intern Med139:109-111, 1979)This publication has 2 references indexed in Scilit:
- Sleep-induced apnea syndromeThe American Journal of Medicine, 1977
- Progesterone for Outpatient Treatment of Pickwickian SyndromeAnnals of Internal Medicine, 1975