STUDIES ON GASTRIC ULCER

10 October 1925

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 85 (15) , 1131
https://doi.org/10.1001/jama.1925.02670150029009

Abstract

It occurred to us that acute or chronic ulcers of the stomach might be produced on the basis of the "Arthus phenomenon," or "local anaphylaxis," studied recently in detail by Opie.¹ METHODS Rabbits were injected with a protein until a skin ulcer was obtained. The specific protein was then injected aseptically into the gastric mucosa. Dogs with a pyloric pouch²were sensitized to a protein. The provocative dose was injected into the mucosa of the pouch, and into the adjacent skin. The precipitin titer of the blood was followed in both series of experiments. RESULTS The gastric mucosa of the rabbits killed at varying intervals presented the following sequence of pathologic changes at the site of injection: (1) local passive hyperemia and edema in from one to two days after injection of the specific protein into the gastric mucosa; (2) induration and necrosis in from two to five

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