Suppression of autoimmunity in nzb mice with steroid‐sensitive x‐radiation‐sensitive syngeneic young thymocytes

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Abstract
NZB mice spontaneously lose thymic regulatory or suppressor cells and subsequently develop autoimmunity and lymphoreticular hyperlasia. Treatment with 2‐week‐old syngeneic thymocytes every 2 weeks starting at 4 weeks of age suppressed these disease manifestations. The active thymocyte subpopulation was found to be sensitive to corticosteroids and X‐irradiation.