New chemotherapeutic nitroheterocycles active against 5-nitroimidazole-resistant strains of trichomonads.

  • 1 January 1981
    • journal article
    • Vol. 31  (1) , 6-8
Abstract
The synthesis and the trichomonacidal activity of some 4-substituted 2-imidazolylquinazoline derivatives are described. The new compounds were highly active against metronidazole-sensitive and metronidazole-resistant strains of trichomonads. This was demonstrated in vitro as well as in various trichomoniasis models in mice and rats after oral treatment.

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