GENETIC-LINKAGE STUDIES WITH CLEFT-LIP AND PALATE - REPORT OF 2 FAMILY STUDIES

  • 1 January 1983
    • journal article
    • research article
    • Vol. 3  (3) , 207-212
Abstract
Genetic linkage studies are reported on 2 families with cleft lip .+-. cleft palate. For the 1st family (LP01) the etiology of the clefting is unknown, and the linkage analyses were done assuming both autosomal dominant and autosomal recessive inheritance. Close linkage is rejected with the Duffy blood group under the dominant model and with 4 loci (Duffy, Kidd, and ABO blood groups and haptoglobin) under the recessive model. The 2nd family (LP02) is a Mexican-American family segregating the van der Woude syndrome with lip pits. The linkage analyses for this autosomal dominant trait excluded close linkage with 7 genetic markers, including 3 on chromosome one. The maximum lod scores were 0.6 with BF (chromosome 6) and 0.4 with the P blood group, which is not yet mapped.