Oncogenes, tumor suppressors and p52 NF-κB
- 23 October 2003
- journal article
- editorial
- Published by Springer Nature in Oncogene
- Vol. 22 (48) , 7553-7556
- https://doi.org/10.1038/sj.onc.1207139
Abstract
A role for the p52 NF-B subunit in tumorigenesis has been steadily emerging since its discovery as a gene associated with chromosomal translocations in B- and T-cell lymphomas. Now Eliopoulos and co-workers have extended these studies to examine the effect of the Epstein–Barr virus (EBV)-encoded latent infection membrane protein 1 (LMP1) on p52. They find that LMP1 stimulates the processing of p100 to p52 NF-B. Moreover, nuclear p52 is also associated with LMP1 expression in tumor tissue biopsies. They also demonstrate that the pathway leading to p100/p52 processing is distinct from that engaged by LMP1 to activate other NF-B subunits through IB degradation. A clearer picture is now developing of the important role that p52 NF-B plays during normal cell growth and how subverting its function can contribute to oncogenesis.Keywords
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