Effect of FUDR on Interferon Production,

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Abstract
Discussion and summary FUDR had no effect on the production of interferon by CE cells, when the inducing virus was chickungunya virus, an RNA virus, or vaccinia virus, a DNA virus. The concentrations of FUDR used inhibited total DNA synthesis and growth of vaccinia virus by about 95%. Thus, under our experimental conditions, it may reasonably be concluded that little or no new DXA synthesis is needed for the production of interferon. Holmes et al(1), working with mumps virus, report that iododeoxyuridine inhibits the production of interferon without any gross toxicity to the cells. They conclude that new DNA synthesis is needed for interferon production. It is difficult to reconcile their findings with ours, unless the rather high levels of IUDR they used exerted a deleterious action on the metabolism of the cells which was not revealed by morphological alterations. The data of Donikian and Stewart(2) do not suggest the need for new DNA synthesis for the production of interferon. It would appear, therefore, that DNA is functioning in its usual way as a template in the interferon producing cell.

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