Immunological nature of genetic resistance of mice to herpes simplex virus type 1 infection.

  • 1 January 1978
    • journal article
    • research article
    • No. 24
Abstract
Treatment of mice genetically resistant to HSV-1 with agents which impair T-cell or macrophage function markedly diminished resistance. Bone marrow transplantation of genetically susceptible mice with marrow from resistant F1 mice produced chimeras resistant to HSV-1. Resistance thus appears to be immunological in nature. Striking similarities were found between resistance to HSV-1 and allogeneic resistance.

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