Prizidilol (SK & F 92657), a new vasodilator with beta-blocking properties in the treatment of essential hypertension
- 1 January 1982
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 23 (5) , 411-415
- https://doi.org/10.1007/bf00605990
Abstract
Summary The antihypertensive effect of a new vasodilator with betablocking properties (SK & F 92657) was investigated in 10 patients with mild to moderate essential hypertension. After a mean treatment period of 26,5 weeks (6,5–49 weeks) blood pressure was significantly reduced, from 168±22/106±6 mmHg to 144±19/94±12 mmHg (pp<0.02). Thus, a mean dose of prizidilol of 410±242 mg/day had a mean blood pressure lowering effect of 24/12 mmHg. In 7 of the 10 patients (70%) diastolic blood pressure could be reduced to 95 mmHg or less. However, the observed haematological side-effects should be carefully monitored in further studies and may limit the clinical use of prizidilol.Keywords
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