Radiation response of mice maintained on a defined diet

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Abstract
Possible radioprotective effects of a defined diet consisting of protein hydrolysates, sucrose, medium chain triglycerides, natural oils and vitamins are investigated in mice. Feeding of this defined diet prior to whole body irradiation is suggested to produce changes in the growth kinetics of intestinal crypt cells resulting in fewer proliferative cells at the time of irradiation and subsequent delay in post-irradiation proliferative regeneration. No other radioprotective effects are found in terms of reduced mortality due to administration of an elemental diet in irradiated mice.

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