PERIPHERAL CIRCULATION DURING EXPERIMENTAL FEVER

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Abstract
The febrile reaction in 9 rabbits injected with typhoid-paratyphoid vaccine invariably caused, in the normally innervated ear, as indicated by temp. changes, a marked constriction of the blood vessels, coming on soon (5-10 min.) after the injection and persisting until the "peak" of the temp. rise had developed. Constriction occurred in only 4 of 9 sympathectomized ears. In some cases vasoconstriction occurred in the sympathectomized ear almost immediately after the injection of vaccine; in others the constriction was much delayed (1-3 hrs. after the injection). Inactivation of the adrenals abolished the immediate but not the delayed vasoconstriction in the sympathectomized vessels. Evidence indicates that destruction of the sympathetic innervation renders the vessels of the ear more sensitive to adrenine than are the normally innervated vessels. The blood vessels of the sympathectomized ear do not dilate so completely as do those of the normal ear when there is general peripheral vasodilatation (i.e., when body temp. is decreasing after a febrile response).

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