FURTHER STUDIES ON OPIATE RECEPTORS THAT MEDIATE ANTI-NOCICEPTION: TOOTH PULP STIMULATION IN THE DOG
Open Access
- 1 October 1980
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 70 (2) , 323-327
- https://doi.org/10.1111/j.1476-5381.1980.tb07939.x
Abstract
1 The antinociceptive activities of morphine, codeine and dextropropoxyphene (μ-agonists), buprenorphine and Mr 2034 [(-)5,9-dimethyl-2-(tetrahydrofurfuryl)-2′-hydroxy-6,7-benzomorphan](k-agonists) have been determined against nociceptive responses to electrical stimulation of the tooth pulp in the conscious dog. 2 Dose-dependent increases in nociceptive thresholds were obtained for all of the analgesic drugs tested at doses within their antinociceptive range as determined in nociceptive pressure and chemical tests in rodents.Keywords
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