Comparison of the effects of the dipeptidyl peptidase inhibitors captopril, ramipril, and enalapril on water intake and sodium appetite of Sprague-Dawley rats.

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Abstract
Two experiments were performed with Sprague-Dawley rats to study the effects of different inhibitors of angiotesnin I converting enzyme (ACE) on water intake and soidum appetite. Subcutaneous administration of low doses either enalapril (MK 421) or ramipril (Hoe 498), like captopril, was dipsogenic. Acute adminstration of ramipril also enhanced the drinking response to peripherally adminstered angiotensin I (Anf I). Higher doses inhibited the drinking response to Ang I, administered acutely either peripherally or centrally. These data provide behavioral evidence that the nonsulfhydryl inhibitors enalarpil and ramipril inhibit brain converting enzyme activity and that they are considerably more potent that captopril. All three of these compounds, administered chronically in food, induced an appetite for sodium chloride (NaCl) solution. Enalapril and ramipril were more potent that captopril. Plasma renin activity was increased by each of these inhibitors, but the magnitude of the increase was not clearly related to the amount of NaCl consumed. The water intake in response to acute adminstration of either Ang I or isoproterenol was reliably increased in rats treated chronically with these inhibitors.

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