Prevention of Myocardial Necrosis by Advanced Pregnancy

Publisher Website
Google Scholar
Abstract
IN THE COURSE of studies on the influence of acute hyperparathyroidism on gestation and fetal development in the albino rat, it was found that advanced pregnancy exerts a remarkable protective action against the toxic sequelae of parathyroid hormone overdosage. This observation led to a systematic investigation of the protection afforded by pregnancy against the deleterious effects of the acute hyperparathyroid state which entail severe myocardial necrosis and nephrocalcinosis. The results of these studies form the subject of the present report. Methods and Materials Albino rats in the first, second, and third week of gestation and nonpregnant female littermates were injected with parathyroid hormone (PTH) subcutaneously, in a dosage of 150 USP units twice daily on 3 successive days. Tail blood was obtained before the first PTH injection and 48 hours later for determination of total calcium1 and inorganic phosphate2 in the serum. Animals surviving the acute hyperparathyroid state

This publication has 0 references indexed in Scilit: