Effects of labetalol and methyldopa on renal function

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Abstract
Renal function studies were performed in human subjects with mild hypertension treated with labetalol (n = 5) and moderate to moderately severe hypertension treated in a random double-blind fashion with either labetalol (n = 6) or methyldopa (n = 6). Drugs were given in doses sufficient to reduce standing diastolic blood pressure to < 90 mm Hg. This was achieved in all subjects without significant side effects. Inulin clearance, p-aminohippurate clearance, filtration fraction, free-water clearance and maximal concentrating ability were assessed before and after 15 days of drug. No alteration in any parameter were noted with labetalol. Inulin clearance fell by 13% (P < 0.05), and filtration fraction fell from 0.23-0.18 (P < 0.02), but other parameters of renal function did not change with methyldopa.